Article
B-Cell Depletion Promotes Aortic Infiltration of Immunosuppressive Cells and Is Protective of Experimental Aortic Aneurysm.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2016
Schaheen Basil, Downs Emily A, Serbulea Vlad, Almenara Camila C P, Spinosa Michael, Su Gang, Zhao Yunge, Srikakulapu Prasad, Butts Cherié, McNamara Coleen A, Leitinger Norbert, Upchurch Gilbert R, Meher Akshaya K, Ailawadi Gorav
Abstract excerpt
OBJECTIVE: B-cell depletion therapy is widely used for treatment of cancers and autoimmune diseases. B cells are abundant in abdominal aortic aneurysms (AAA); however, it is unknown whether B-cell depletion therapy affects AAA growth. Using experimental models of murine AAA, we aim to examine the effect of B-cell depletion on AAA formation. APPROACH AND RESULTS: Wild-type or apolipoprotein E-knockout mice were...
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