Article
Two-factor authentication underpins the precision of the piRNA pathway.
Nature - 1 Oct 2024
Dias Mirandela Madeleine, Zoch Ansgar, Leismann Jessica, Webb Shaun, Berrens Rebecca V, Valsakumar Devisree, Kabayama Yuka, Auchynnikava Tania, Schito Martina, Chowdhury Tamoghna, MacLeod David, Xiang Xinyu, Zou Juan, Rappsilber Juri, Allshire Robin C, Voigt Philipp, Cook Atlanta G, Barau Joan, O'Carroll Dónal
Abstract excerpt
The PIWI-interacting RNA (piRNA) pathway guides the DNA methylation of young, active transposons during germline development in male mice1. piRNAs tether the PIWI protein MIWI2 (PIWIL4) to the nascent transposon transcript, resulting in DNA methylation through SPOCD1 (refs. 2-5). Transposon methylation requires great precision: every copy needs to be methylated but off-target methylation must be avoided. However,...
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