Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.

doi:10.1371/journal.pgen.1006812

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Article

Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.

PLoS genetics - 1 Jun 2017

Shungin Dmitry, Deng Wei Q, Varga Tibor V, Luan Jian'an, Mihailov Evelin, Metspalu Andres, Morris Andrew P, Forouhi Nita G, Lindgren Cecilia, Magnusson Patrik K E, Pedersen Nancy L, Hallmans Göran, Chu Audrey Y, Justice Anne E, Graff Mariaelisa, Winkler Thomas W, Rose Lynda M, Langenberg Claudia, Cupples L Adrienne, Ridker Paul M, Wareham Nicholas J, Ong Ken K, Loos Ruth J F, Chasman Daniel I, Ingelsson Erik, Kilpeläinen Tuomas O, Scott Robert A, Mägi Reedik, Paré Guillaume, Franks Paul W

Abstract excerpt

Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (Pv), G×E interaction effects (with smoking and physical activity), and marginal genetic effects (Pm)....

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Identifiers

PMID: 28614350
DOI: 10.1371/journal.pgen.1006812
PMCID: PMC5489225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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