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Article

Non-linear interaction between physical activity and polygenic risk score of body mass index in Danish and Russian populations.

PloS one - 1 Jan 2021

Borisevich Dmitrii, Schnurr Theresia M, Engelbrechtsen Line, Rakitko Alexander, Ängquist Lars, Ilinsky Valery, Aadahl Mette, Grarup Niels, Pedersen Oluf, Sørensen Thorkild I A, Hansen Torben

Abstract excerpt

Body mass index (BMI) is a highly heritable polygenic trait. It is also affected by various environmental and behavioral risk factors. We used a BMI polygenic risk score (PRS) to study the interplay between the genetic and environmental factors defining BMI. First, we generated a BMI PRS that explained more variance than a BMI genetic risk score (GRS), which was using only genome-wide significant BMI-associated...

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Identifiers

PMID: 34662357
DOI: 10.1371/journal.pone.0258748
PMCID: PMC8523041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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