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Article

Gene-environment interaction explains a part of missing heritability in human body mass index.

Communications biology - 25 Mar 2023

Jung Hae-Un, Kim Dong Jun, Baek Eun Ju, Chung Ju Yeon, Ha Tae Woong, Kim Han-Kyul, Kang Ji-One, Lim Ji Eun, Oh Bermseok

Abstract excerpt

Gene-environment (G×E) interaction could partially explain missing heritability in traits; however, the magnitudes of G×E interaction effects remain unclear. Here, we estimate the heritability of G×E interaction for body mass index (BMI) by subjecting genome-wide interaction study data of 331,282 participants in the UK Biobank to linkage disequilibrium score regression (LDSC) and linkage disequilibrium adjusted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36966243
DOI: 10.1038/s42003-023-04679-4
PMCID: PMC10039928

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