Article
The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs.
Cell reports - 10 Mar 2020
Laver John D, Ly Jimmy, Winn Jamie K, Karaiskakis Angelo, Lin Sichun, Nie Kun, Benic Giulia, Jaberi-Lashkari Nima, Cao Wen Xi, Khademi Alireza, Westwood J Timothy, Sidhu Sachdev S, Morris Quaid, Angers Stephane, Smibert Craig A, Lipshitz Howard D
Abstract excerpt
G3BP RNA-binding proteins are important components of stress granules (SGs). Here, we analyze the role of the Drosophila G3BP Rasputin (RIN) in unstressed cells, where RIN is not SG associated. Immunoprecipitation followed by microarray analysis identifies over 550 mRNAs that copurify with RIN. The mRNAs found in SGs are long and translationally silent. In contrast, we find that RIN-bound mRNAs, which encode core...
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