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Article

Differential connectivity of splicing activators and repressors to the human spliceosome

5 Jun 2015

Abstract excerpt

BACKGROUND: During spliceosome assembly, protein-protein interactions (PPI) are sequentially formed and disrupted to accommodate the spatial requirements of pre-mRNA substrate recognition and catalysis. Splicing activators and repressors, such as SR proteins and hnRNPs, modulate spliceosome assembly and regulate alternative splicing. However, it remains unclear how they differentially interact with the core...

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PMID: 26047612
DOI: 10.1186/s13059-015-0682-5

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