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Article

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells

29 Dec 2020

Abstract excerpt

In pancreatic β-cells, the expression of the splicing factor SRSF6 is regulated by GLIS3, a transcription factor encoded by a diabetes susceptibility gene. SRSF6 down-regulation promotes β-cell demise through splicing dysregulation of central genes for β-cells function and survival, but how RNAs are targeted by SRSF6 remains poorly understood. Here, we define the SRSF6 binding landscape in the human pancreatic...

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PMID: 33376132
DOI: 10.26508/lsa.202000825

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