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Article

Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function.

Cerebral cortex (New York, N.Y. : 1991) - 1 Jul 2018

Lu Nan-Nan, Tan Chao, Sun Ning-He, Shao Ling-Xiao, Liu Xiu-Xiu, Gao Yin-Ping, Tao Rong-Rong, Jiang Quan, Wang Cheng-Kun, Huang Ji-Yun, Zhao Kui, Wang Guang-Fa, Liu Zhi-Rong, Fukunaga Kohji, Lu Ying-Mei, Han Feng

Abstract excerpt

Grb2-associated-binding protein 1 (Gab1) is a docking/scaffolding molecule known to play an important role in cell growth and survival. Here, we report that Gab1 is decreased in cholinergic neurons in Alzheimer's disease (AD) patients and in a mouse model of AD. In mice, selective ablation of Gab1 in cholinergic neurons in the medial septum impaired learning and memory and hippocampal long-term potentiation. Gab1...

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Identifiers

PMID: 28591834
DOI: 10.1093/cercor/bhx141
PMCID: PMC7189983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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