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Article

The Familial dementia gene ITM2b/BRI2 facilitates glutamate transmission via both presynaptic and postsynaptic mechanisms.

Scientific reports - 19 Mar 2019

Yao Wen, Yin Tao, Tambini Marc D, D'Adamio Luciano

Abstract excerpt

Mutations in the Integral membrane protein 2B (ITM2b/BRI2) gene, which codes for a protein called BRI2, cause familial British and Danish dementia (FBD and FDD). Loss of BRI2 function and/or accumulation of amyloidogenic mutant BRI2-derived peptides have been proposed to mediate FDD and FBD pathogenesis by impairing synaptic Long-term potentiation (LTP). However, the precise site and nature of the synaptic...

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Identifiers

PMID: 30890756
DOI: 10.1038/s41598-019-41340-9
PMCID: PMC6425013

Genes

CA1
CA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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