Article

KIBRA-PKCγ signaling pathway modulates memory performance in mice and humans

2021-10-28

Abstract excerpt

Human memory is a polygenic cognitive trait that is fundamental to individual competence. Genome-wide association studies (GWAS) have identified KIBRA as a novel gene associated with human memory performance. KIBRA interacts with AMPA receptors (AMPARs) and proteins essential for synaptic plasticity. The deletion of Kibra in mice impairs synaptic plasticity and learning and memory. However, the molecular basis t...

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Literature Corpus work: dcd9eef9-be98-53e2-9184-6af52dd854e5
DOI: 10.1101/2021.10.26.465926

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