Article

Revealing Notch-dependencies in synaptic targets associated with Alzheimer’s disease

2021-03-22

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the major cause of dementia. There is evidence that synaptic dysfunction and perturbation of Excitatory/Inhibitory (E/I) balance arise at the early stages of AD, altering the normal neural network activity, and leading to cognitive decline. Recent studies have identified Notch signaling as a contributor of neurodegenerative advancement includ...

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Literature Corpus work: a20eb7e3-b67f-5269-ae3f-aa0e6d10c585
DOI: 10.1101/2021.03.22.436438

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