Article

Activation of the CA2-vCA1 pathway reverses social discrimination dysfunction in <i>Shank3B</i> knockout mice

2022-03-29

Abstract excerpt

Social memory dysfunction is a feature of several neuropsychiatric and neurodevelopmental disorders. Mutation or deletion of the SHANK3 gene, which codes for a synaptic scaffolding protein, has been linked to autism spectrum disorder (ASD) and Phelan-McDermid syndrome, conditions associated with impairments in social memory. Shank3B knockout (KO) mice exhibit several behavioral abnormalities that may be analogou...

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Literature Corpus work: e6441271-9f99-5493-bc6e-13d276199f41
DOI: 10.1101/2022.03.28.486130

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