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Article

Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus.

Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2009

Tretter Verena, Revilla-Sanchez Raquel, Houston Catriona, Terunuma Miho, Havekes Robbert, Florian Cédrick, Jurd Rachel, Vithlani Mansi, Michels Guido, Couve Andrés, Sieghart Werner, Brandon Nicholas, Abel Ted, Smart Trevor G, Moss Stephen J

Abstract excerpt

Fast synaptic inhibition in the brain is largely mediated by gamma-aminobutyric acid receptors (GABA(A)R). While the pharmacological manipulation of GABA(A)R function by therapeutic agents, such as benzodiazepines can have profound effects on neuronal excitation and behavior, the endogenous mechanisms neurons use to regulate the efficacy of synaptic inhibition and their impact on behavior remains poorly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19903874
DOI: 10.1073/pnas.0908840106
PMCID: PMC2785288

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