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<i>TrkA</i>Gene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic Circuitry

21 Mar 2012

Abstract excerpt

Dysfunction of basal forebrain cholinergic neurons (BFCNs) is an early pathological hallmark of Alzheimer's disease (AD). Numerous studies have indicated that nerve growth factor (NGF) supports survival and phenotypic differentiation of BFCNs. Consistent with a potential link to AD pathogenesis, TrkA, a NGF receptor, is expressed in cholinergic forebrain neuronal populations including those in BF and striatum,...

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PMID: 22442072
DOI: 10.1523/jneurosci.6314-11.2012

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