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Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer’s disease

13 Jan 2024

Abstract excerpt

Alzheimer's disease is neurodegenerative and characterized by progressive cognitive impairment. Synaptic dysfunction appears in the early stage of Alzheimer's disease and is significantly correlated with cognitive impairment. However, the specific regulatory mechanism remains unclear. Here, we found the transcription factor Maf1 to be upregulated in Alzheimer's disease and determined that conditional knockout of...

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PMID: 38226680
DOI: 10.1093/brain/awae015

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