Article
Genetic selection for mistranslation rescues a defective co-chaperone in yeast.
Nucleic acids research - 7 Apr 2017
Hoffman Kyle S, Berg Matthew D, Shilton Brian H, Brandl Christopher J, O'Donoghue Patrick
Abstract excerpt
Despite the general requirement for translation fidelity, mistranslation can be an adaptive response. We selected spontaneous second site mutations that suppress the stress sensitivity caused by a Saccharomyces cerevisiae tti2 allele with a Leu to Pro mutation at residue 187, identifying a single nucleotide mutation at the same position (C70U) in four tRNAProUGG genes. Linkage analysis and suppression by...
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