Article
Widespread temperature sensitivity and tRNA decay due to mutations in a yeast tRNA.
RNA (New York, N.Y.) - 1 Mar 2018
Payea Matthew J, Sloma Michael F, Kon Yoshiko, Young David L, Guy Michael P, Zhang Xiaoju, De Zoysa Thareendra, Fields Stanley, Mathews David H, Phizicky Eric M
Abstract excerpt
Microorganisms have universally adapted their RNAs and proteins to survive at a broad range of temperatures and growth conditions. However, for RNAs, there is little quantitative understanding of the effects of mutations on function at high temperatures. To understand how variant tRNA function is affected by temperature change, we used the tRNA nonsense suppressor SUP4oc of the yeast Saccharomyces cerevisiae to...
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