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Article

Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

2 Jun 2017

Abstract excerpt

PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of...

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PMID: 28572158
DOI: 10.1161/atvbaha.117.309451

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