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Article

Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease

1 Jan 2005

Abstract excerpt

Although plasminogen activator inhibitor 1 (PAI-1) is one of the primary regulators of the fibrinolytic system, it also has dramatic effects on cell adhesion, detachment and migration. PAI-1 also differs from other serine protease inhibitors (serpins) in that it is a trace protein in plasma, it has a short half-life in vivo, its synthesis is highly regulated, and it binds to the adhesive glycoprotein vitronectin...

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Identifiers

PMID: 15841306
DOI: 10.1160/th05-01-0033

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