Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1

2 Nov 2021

Abstract excerpt

The mechanisms underlying the development of glomerular lesions during aging are largely unknown. It has been suggested that senescence might play a role, but the pathophysiological link between senescence and lesion development remains unexplained. Here, we uncovered an unexpected role for glomerular endothelial cells during aging. In fact, we discovered a detrimental cross-talk between senescent endothelial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Kidney Disease and Diabetes
Share to Renal and related cancers
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34725920
DOI: 10.15252/emmm.202114146

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1PMID 34725920Read ↗

Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of SenescenceSemantic proximity Read ↗

PAI-1 is a common driver of aging and diverse diseasesSemantic proximity Read ↗

Cellular senescence in the aging and diseased kidneySemantic proximity Read ↗

Factors and Pathways Modulating Endothelial Cell Senescence in Vascular AgingSemantic proximity Read ↗

Epigenetically regulated inflammation in vascular senescence and renal progression of chronic kidney diseaseSemantic proximity Read ↗

Podocyte senescence: from molecular mechanisms to therapeuticsSemantic proximity Read ↗

Novel Contributors and Mechanisms of Cellular Senescence in Hypertension-Associated Premature Vascular AgingSemantic proximity Read ↗

AQP1 Differentially Orchestrates Endothelial Cell SenescenceSemantic proximity Read ↗

Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseasesSemantic proximity Read ↗

AQP1 differentially orchestrates endothelial cell senescenceSemantic proximity Read ↗

Molecular aspects of renal senescenceSemantic proximity Read ↗

Upregulated PD-1 Signaling is an Important Antagonist to Glomerular Health in Aged KidneysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.