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Good or bad: Paradox of plasminogen activator inhibitor 1 (PAI-1) in digestive system tumors

6 Mar 2023

Abstract excerpt

The fibrinolytic system is involved in many physiological functions, among which the important members can interact with each other, either synergistically or antagonistically to participate in the pathogenesis of many diseases. Plasminogen activator inhibitor 1 (PAI-1) acts as a crucial element of the fibrinolytic system and functions in an anti-fibrinolytic manner in the normal coagulation process. It inhibits...

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PMID: 36889376
DOI: 10.1016/j.canlet.2023.216117

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