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Article

Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders.

Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 May 2009

Oishi Katsutaka

Abstract excerpt

Plasma PAI-1 levels robustly fluctuate in a circadian manner and consequently contribute to hypofibrinolysis during the early morning. The circadian expression of PAI-1 gene is thought to be directly regulated by the circadian clock proteins such as CLOCK and BMAL1/BMAL2 which drive the endogenous biological clock. Plasma PAI-1 levels are increased in the beginning of the active phase in both diurnal humans and...

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Source

Identifiers

PMID: 19387897
DOI: 10.1080/10641960902822468

Genes

BMAL1
BMAL2
CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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