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Article

Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent.

Current drug targets - 1 Sept 2007

Cale Jacqueline M, Lawrence Daniel A

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA, respectively). PAI-1 also interacts with non-proteinase targets such as vitronectin, heparin, and several endocytic receptors of the low-density lipoprotein-receptor family, including the low-density lipoprotein-receptor related protein (LRP) and the very low-density...

Topics

Animals
Humans
Mutation
Plasminogen Activator Inhibitor 1
Protein Structure, Secondary
Serine Proteinase Inhibitors
Structure-Activity Relationship
Transcription, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17896949
DOI: 10.2174/138945007781662337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent.PMID 17896949Read ↗

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