The plasminogen activator inhibitor-1 paradox in cancer: a mechanistic understanding.

doi:10.1007/s10555-019-09806-4

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Article

The plasminogen activator inhibitor-1 paradox in cancer: a mechanistic understanding.

Cancer metastasis reviews - 1 Sept 2019

Kubala Marta Helena, DeClerck Yves Albert

Abstract excerpt

The paradoxical pro-tumorigenic function of plasminogen activator inhibitor 1 (PAI-1, aka Serpin E1) in cancer progression and metastasis has been the subject of an abundant scientific literature that has pointed to a pro-angiogenic role, a growth and migration stimulatory function, and an anti-apoptotic activity, all directed toward promoting tumor growth, cancer cell survival, and metastasis. With uPA, PAI-1 is...

Topics

Animals
Biomarkers, Tumor
Disease Progression
Humans
Models, Molecular
Neoplasms
Plasminogen Activator Inhibitor 1
Polymorphism, Single Nucleotide
Randomized Controlled Trials as Topic

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Identifiers

PMID: 31734763
DOI: 10.1007/s10555-019-09806-4
PMCID: PMC7001780

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