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Article

PAI-1 is a common driver of aging and diverse diseases

18 Jul 2025

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) is a key driver of aging and contributes to diverse pathologies. This review examines PAI-1's multifaceted contributions to aging. At the cellular level, PAI-1 amplifies senescence, exhausts stem cell niches, and disrupts metabolism. These cellular alterations translate into physiological decline: PAI-1 drives cardiovascular aging by promoting vascular senescence and...

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Share to Genetics, Aging, and Longevity in Model Organisms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40684985
DOI: 10.1016/j.bj.2025.100892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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