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Article

A null mutation in SERPINE1 protects against biological aging in humans.

Science advances - 1 Nov 2017

Khan Sadiya S, Shah Sanjiv J, Klyachko Ekaterina, Baldridge Abigail S, Eren Mesut, Place Aaron T, Aviv Abraham, Puterman Eli, Lloyd-Jones Donald M, Heiman Meadow, Miyata Toshio, Gupta Sweta, Shapiro Amy D, Vaughan Douglas E

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) has been shown to be a key component of the senescence-related secretome and a direct mediator of cellular senescence. In murine models of accelerated aging, genetic deficiency and targeted inhibition of PAI-1 protect against aging-like pathology and prolong life span. However, the role of PAI-1 in human longevity remains unclear. We hypothesized that a rare...

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Identifiers

PMID: 29152572
DOI: 10.1126/sciadv.aao1617
PMCID: PMC5687852

Genes

SERPINE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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