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Three Decades of Research on Plasminogen Activator Inhibitor-1: A Multifaceted Serpin

16 Mar 2013

Abstract excerpt

Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator and therefore plays an important role in the plasminogen-plasmin system. PAI-1 is involved in a variety of cardiovascular diseases (mainly through inhibition of t-PA) as well as in cell migration and tumor development (mainly through inhibition of u-PA and interaction with...

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PMID: 23504606
DOI: 10.1055/s-0033-1334487

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Three Decades of Research on Plasminogen Activator Inhibitor-1: A Multifaceted SerpinPMID 23504606Read ↗

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Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancementsSemantic proximity Read ↗

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