Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antagonistic actions of two human Pan3 isoforms on global mRNA turnover.

RNA (New York, N.Y.) - 1 Sept 2017

Chen Chyi-Ying A, Zhang Yueqiang, Xiang Yu, Han Leng, Chang Jeffrey T, Shyu Ann-Bin

Abstract excerpt

Deadenylation is a fundamental process that regulates eukaryotic gene expression. Mammalian deadenylation exhibits biphasic kinetics, with the Pan2-Pan3 and Ccr4-Caf1 deadenylase complexes mediating the first and second phase, respectively; however, the significance of the biphasic nature of deadenylation in mRNA turnover remains unclear. In this study, we discovered that two distinct isoforms of human Pan3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exoribonucleases
Share to Gene Knockdown Techniques
Share to MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Poly A

Share to Polyadenylation

Share to Protein Interaction Domains and Motifs

Share to Protein Isoforms

Share to RNA Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 28559491
DOI: 10.1261/rna.061556.117
PMCID: PMC5558910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antagonistic actions of two human Pan3 isoforms on global mRNA turnover.PMID 28559491Read ↗

Molecular Insights into mRNA Polyadenylation and DeadenylationSemantic proximity Read ↗

TREND-DB – A Transcriptome-wide Atlas of the Dynamic Landscape of Alternative PolyadenylationSemantic proximity Read ↗

M6A RNA methylation in biliary tract cancer: the function roles and potential therapeutic implicationsSemantic proximity Read ↗

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptomeSemantic proximity Read ↗

UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cellsSemantic proximity Read ↗

Alternative cleavage and polyadenylation: key regulatory mechanisms in health and diseaseSemantic proximity Read ↗

To polyadenylate or to deadenylateSemantic proximity Read ↗

The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.Semantic proximity Read ↗

A pan-cancer analysis of the core pre-mRNA 3′ end processing factors, and their association with prognosis, tumor microenvironment, and potential targetsSemantic proximity Read ↗

Positive and negative regulation of poly(A) nuclease.Semantic proximity Read ↗

Large-scale alternative polyadenylation (APA)-wide association studies to identify putative susceptibility genes in human common cancersSemantic proximity Read ↗

CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone processingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.