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Article

A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers.

Nature communications - 30 May 2017

Pisignano Giuseppina, Napoli Sara, Magistri Marco, Mapelli Sarah N, Pastori Chiara, Di Marco Stefano, Civenni Gianluca, Albino Domenico, Enriquez Claudia, Allegrini Sara, Mitra Abhishek, D'Ambrosio Gioacchino, Mello-Grand Maurizia, Chiorino Giovanna, Garcia-Escudero Ramon, Varani Gabriele, Carbone Giuseppina M, Catapano Carlo V

Abstract excerpt

Long noncoding RNAs are emerging players in the epigenetic machinery with key roles in development and diseases. Here we uncover a complex network comprising a promoter-associated noncoding RNA (paRNA), microRNA and epigenetic regulators that controls transcription of the tumour suppressor E-cadherin in epithelial cancers. E-cadherin silencing relies on the formation of a complex between the paRNA and...

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Identifiers

PMID: 28555645
DOI: 10.1038/ncomms15622
PMCID: PMC5459991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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