Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional SNP regulates E-cadherin expression by dynamically remodeling the 3D structure of a promoter-associated non-coding RNA transcript.

Nucleic acids research - 28 Oct 2022

Sharma Shrikant, Pisignano Giuseppina, Merulla Jessica, Catapano Carlo V, Varani Gabriele

Abstract excerpt

Transcription of E-cadherin, a tumor suppressor that plays critical roles in cell adhesion and the epithelial-mesenchymal transition, is regulated by a promoter-associated non-coding RNA (paRNA). The sense-oriented paRNA (S-paRNA) includes a functional C/A single nucleotide polymorphism (SNP rs16260). The A-allele leads to decreased transcriptional activity and increased prostate cancer risk. The polymorphic site...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Gene Expression Regulation, Neoplastic

Share to MicroRNAs

Share to Nucleotides

Share to Polymorphism, Single Nucleotide

Share to RNA, Untranslated

Source

Open in PubMed Open full text

Identifiers

PMID: 36243981
DOI: 10.1093/nar/gkac875
PMCID: PMC9638923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

A functional SNP regulates E-cadherin expression by dynamically remodeling the 3D structure of a promoter-associated non-coding RNA transcript.PMID 36243981Read ↗

A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers.Semantic proximity Read ↗

Single-nucleotide polymorphism in the E-cadherin gene promoter modifies the risk of prostate cancer.Semantic proximity Read ↗

Single nucleotide polymorphisms affect RNA-protein interactions at a distance through modulation of RNA secondary structures.Semantic proximity Read ↗

Conformational Effects of a Cancer-Linked Mutation in Pri-miR-30c RNA.Semantic proximity Read ↗

Structural architecture of the human long non-coding RNA, steroid receptor RNA activator.Semantic proximity Read ↗

Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damageSemantic proximity Read ↗

Genetic variants in the integrin gene predicted microRNA-binding sites were associated with the risk of prostate cancer.Semantic proximity Read ↗

A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer.Semantic proximity Read ↗

Exploring the molecular basis of RNA recognition by the dimeric RNA-binding protein via molecular simulation methods.Semantic proximity Read ↗

A genetic variant alters the secondary structure of the lncRNA H19 and is associated with Dilated CardiomyopathySemantic proximity Read ↗

A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.