Article
Non-coding RNAs as regulators of gene expression and epigenetics.
Cardiovascular research - 1 Jun 2011
Kaikkonen Minna U, Lam Michael T Y, Glass Christopher K
Abstract excerpt
Genome-wide studies have revealed that mammalian genomes are pervasively transcribed. This has led to the identification and isolation of novel classes of non-coding RNAs (ncRNAs) that influence gene expression by a variety of mechanisms. Here we review the characteristics and functions of regulatory ncRNAs in chromatin remodelling and at multiple levels of transcriptional and post-transcriptional regulation. We...
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