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Article

Genome-wide analysis of noncoding regulatory mutations in cancer.

Nature genetics - 1 Nov 2014

Weinhold Nils, Jacobsen Anders, Schultz Nikolaus, Sander Chris, Lee William

Abstract excerpt

Cancer primarily develops because of somatic alterations in the genome. Advances in sequencing have enabled large-scale sequencing studies across many tumor types, emphasizing the discovery of alterations in protein-coding genes. However, the protein-coding exome comprises less than 2% of the human genome. Here we analyze the complete genome sequences of 863 human tumors from The Cancer Genome Atlas and other...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25261935
DOI: 10.1038/ng.3101
PMCID: PMC4217527

Genes

SDHD
PLEKHS1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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