Article
Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders.
Cell cycle (Georgetown, Tex.) - 15 Oct 2011
Glinskii Anna B, Ma Shuang, Ma Jun, Grant Denise, Lim Chang-Uk, Guest Ian, Sell Stewart, Buttyan Ralph, Glinsky Gennadi V
Abstract excerpt
The mechanistic relevance of intergenic disease-associated genetic loci (IDAGL) containing highly statistically significant disease-linked SNPs remains unknown. Here, we present experimental and clinical evidence supporting the importantance of the role of IDAGL in human diseases. A targeted RT-PCR screen coupled with sequencing of purified PCR products detects widespread transcription at multiple IDAGL and...
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