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Article

PIWI-interacting RNA 021285 is involved in breast tumorigenesis possibly by remodeling the cancer epigenome.

Carcinogenesis - 1 Oct 2015

Fu Alan, Jacobs Daniel I, Hoffman Aaron E, Zheng Tongzhang, Zhu Yong

Abstract excerpt

Although PIWI-interacting RNAs (piRNAs) account for the largest class of the small non-coding RNA superfamily, virtually nothing is known of their function in human carcinogenesis. Once thought to be expressed solely in the germ line where they safeguard the genome against transposon-induced insertional mutations, piRNAs are now believed to play an active role in somatic gene regulation through sequence-specific...

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Share to Carcinogenesis
Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to GTPase-Activating Proteins

Share to Neoplasm Invasiveness

Share to RNA, Small Interfering

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Source

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Identifiers

PMID: 26210741
DOI: 10.1093/carcin/bgv105
PMCID: PMC5006152

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