Article
Histone H3 K27M mutations in adult cerebellar high-grade gliomas.
Brain tumor pathology - 1 Jul 2017
Nakata Satoshi, Nobusawa Sumihito, Yamazaki Tatsuya, Osawa Tadashi, Horiguchi Keishi, Hashiba Yasuhiro, Yaoita Hiroyuki, Matsumura Nozomi, Ikota Hayato, Hirato Junko, Yoshimoto Yuhei, Yokoo Hideaki
Abstract excerpt
Adult cerebellar high-grade gliomas (HGG) are rare and their molecular basis has not been fully elucidated. Although a diffuse midline glioma H3 K27M-mutant, a recently characterized variant of HGG, was reported to occasionally occur in the cerebellum, adult cases were rarely tested for this mutation; only five mutant cases have been reported to date. It currently remains unknown whether H3 K27M-mutant cerebellar...
Topics
- Adult
- Aged
- Brain Neoplasms
- Female
- Glioma
- Histones
- Humans
- Male
- Mutation
- Neoplasm Staging