Article
Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas.
Acta neuropathologica - 1 Nov 2014
Bechet Denise, Gielen Gerrit G H, Korshunov Andrey, Pfister Stefan M, Rousso Caterina, Faury Damien, Fiset Pierre-Olivier, Benlimane Naciba, Lewis Peter W, Lu Chao, David Allis C, Kieran Mark W, Ligon Keith L, Pietsch Torsten, Ellezam Benjamin, Albrecht Steffen, Jabado Nada
Abstract excerpt
Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous p.Lys27Met (K27M) mutations in both H3.3 and H3.1 variants, is associated with rapid fatal outcome, and occurs specifically in HGA of the midline in children and young adults. This includes...
Topics
- Adolescent
- Astrocytoma
- Brain
- Brain Neoplasms
- Child
- Cohort Studies
- DNA Mutational Analysis
- Female
- Genotype
- Histones