Article
A case report of adult cerebellar high-grade glioma with H3.1 K27M mutation: a rare example of an H3 K27M mutant cerebellar tumor.
Brain tumor pathology - 1 Jan 2018
Funata Nobuaki, Nobusawa Sumihito, Nakata Satoshi, Yamazaki Tatsuya, Takabagake Kazuhiko, Koike Tsukasa, Maegawa Tatsuya, Yamada Ryoji, Shinoura Nobusada, Mine Yutaka
Abstract excerpt
Diffuse midline glioma, H3 K27M mutant, is newly recognized as a distinct category, which usually arises in the brain stem, thalamus or spinal cord of children, and young adults. The oncogenic H3 K27M mutation involves H3.3 (encoded by H3F3A) or H3.1 (encoded by HIST1H3B/HIST1H3C), and the incidence of each mutation differs among the primary sites. Recently, several papers have reported that cerebellar high-grade...
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