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Article

H3K27M mutation in adult cerebellar glioblastoma.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Jan 2020

Lu Victor M, Akinduro Oluwaseun O, Daniels David J

Abstract excerpt

A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel...

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Identifiers

PMID: 31843430
DOI: 10.1016/j.jocn.2019.11.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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