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Article

Low-Grade Gemistocytic Morphology in H3 G34R-Mutant Gliomas and Concurrent K27M Mutation: Clinicopathologic Findings.

Journal of neuropathology and experimental neurology - 1 Oct 2020

Morris Meaghan, Driscoll Meghan, Henson John W, Cobbs Charles, Jiang LiQun, Gocke Christopher D, Chen Liam, Rodriguez Fausto J

Abstract excerpt

Mutations in histone H3 are key molecular drivers of pediatric and young adult high-grade gliomas. Histone H3 G34R mutations occur in hemispheric high-grade gliomas and H3 K27M mutations occur in aggressive, though histologically diverse, midline gliomas. Here, we report 2 rare cases of histologically low-grade gliomas with gemistocytic morphology and sequencing-confirmed histone H3 G34R mutations. One case is a...

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Identifiers

PMID: 32954438
DOI: 10.1093/jnen/nlaa101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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