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Article

H3K27M mutant glioma: Disease definition and biological underpinnings.

Neuro-oncology - 3 May 2024

Saratsis Amanda M, Knowles Truman, Petrovic Antonela, Nazarian Javad

Abstract excerpt

High-grade glioma (HGG) is the most common cause of cancer death in children and the most common primary central nervous system tumor in adults. While pediatric HGG was once thought to be biologically similar to the adult form of disease, research has shown these malignancies to be significantly molecularly distinct, necessitating distinct approaches to their clinical management. However, emerging data have shown...

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Identifiers

PMID: 37818718
DOI: 10.1093/neuonc/noad164
PMCID: PMC11066930

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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