Article
Prevalence and clinicopathological features of H3.3 G34-mutant high-grade gliomas: a retrospective study of 411 consecutive glioma cases in a single institution.
Brain tumor pathology - 1 Jul 2017
Yoshimoto Koji, Hatae Ryusuke, Sangatsuda Yuhei, Suzuki Satoshi O, Hata Nobuhiro, Akagi Yojiro, Kuga Daisuke, Hideki Murata, Yamashita Koji, Togao Osamu, Hiwatashi Akio, Iwaki Toru, Mizoguchi Masahiro, Iihara Koji
Abstract excerpt
A recurrent glycine-to-arginine/valine alteration at codon 34 (G34R/V) within H3F3A, a gene that encodes the replication-independent histone variant H3.3, reportedly occurs exclusively in pediatric glioblastomas. However, the clinicopathological and biological significances of this mutation have not been completely elucidated; especially, no such data exist for tumor samples from Japanese patients. We analyzed...
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