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Article

Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice.

Journal of neuroinflammation - 25 May 2017

Qu Wenhui, Johnson Andrea, Kim Joo Hyun, Lukowicz Abigail, Svedberg Daniel, Cvetanovic Marija

Abstract excerpt

BACKGROUND: Polyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative disease characterized by motor deficits, cerebellar neurodegeneration, and gliosis. Currently, there are no treatments available to delay or ameliorate SCA1. We have examined the effect of depleting microglia during the early stage of disease by...

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Identifiers

PMID: 28545543
DOI: 10.1186/s12974-017-0880-z
PMCID: PMC5445366

Genes

ATXN1

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