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Article

Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Oct 2004

Zu Tao, Duvick Lisa A, Kaytor Michael D, Berlinger Michael S, Zoghbi Huda Y, Clark H Brent, Orr Harry T

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant, polyglutamine-induced neurodegenerative disorder that results in loss of motor coordination caused primarily by a disruption of cerebellar Purkinje cell function. In this study, we developed a conditional SCA1 mouse model to examine whether stopping expression of mutant ataxin-1 alters the disease phenotype. After cessation of SCA1[82Q] transgene...

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Identifiers

PMID: 15470152
DOI: 10.1523/JNEUROSCI.2978-04.2004
PMCID: PMC6729947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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