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Article

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP).

Neurobiology of disease - 1 Feb 2015

Chitu Violeta, Gokhan Solen, Gulinello Maria, Branch Craig A, Patil Madhuvati, Basu Ranu, Stoddart Corrina, Mehler Mark F, Stanley E Richard

Abstract excerpt

Mutations in the colony stimulating factor-1 receptor (CSF1R) that abrogate the expression of the affected allele or lead to the expression of mutant receptor chains devoid of kinase activity have been identified in both familial and sporadic cases of ALSP. To determine the validity of the Csf1r heterozygous mouse as a model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) we...

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Identifiers

PMID: 25497733
DOI: 10.1016/j.nbd.2014.12.001
PMCID: PMC4323933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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