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Article

Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.

Neuroscience - 19 Mar 2015

Cvetanovic M, Ingram M, Orr H, Opal P

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is an incurable, dominantly inherited neurodegenerative disease of the cerebellum caused by a polyglutamine-repeat expansion in the protein ataxin-1 (ATXN1). While analysis of human autopsy material indicates significant glial pathology in SCA1, previous research has focused on characterizing neuronal dysfunction. In this study, we characterized astrocytic and microglial...

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Source

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Identifiers

PMID: 25595967
DOI: 10.1016/j.neuroscience.2015.01.003
PMCID: PMC4344857

Genes

ATXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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