Article

Glial cell activation precedes neurodegeneration in the cerebellar cortex of the YG8-800 murine model of Friedreich’s ataxia

2024-05-17

Abstract excerpt

Friedreich’s ataxia is a hereditary neurodegenerative disorder resulting from reduced levels of the protein frataxin due to an expanded GAA repeat in the FXN gene. This deficiency causes progressive degeneration of specific neuronal populations in the cerebellum and the consequent loss of movement coordination and equilibrium, some of the main symptoms observed in affected individuals. Similar to other neurodegen...

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Literature Corpus work: cf1c6d5b-a8fd-5b63-8a96-04be9bb20f32
DOI: 10.1101/2024.05.17.594658

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