Article
Clinical and Genetic Associations of Objectively Identified Interstitial Changes in Smokers.
Chest - 1 Oct 2017
Ash Samuel Y, Harmouche Rola, Putman Rachel K, Ross James C, Diaz Alejandro A, Hunninghake Gary M, Onieva Onieva Jorge, Martinez Fernando J, Choi Augustine M, Lynch David A, Hatabu Hiroto, Rosas Ivan O, San Jose Estepar Raul, Washko George R
Abstract excerpt
BACKGROUND: Smoking-related lung injury may manifest on CT scans as both emphysema and interstitial changes. We have developed an automated method to quantify interstitial changes and hypothesized that this measurement would be associated with lung function, quality of life, mortality, and a mucin 5B (MUC5B) polymorphism. METHODS: Using CT scans from the Genetic Epidemiology of COPD Study, we objectively labeled...
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