Article
Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers.
Thorax - 1 Nov 2018
Ash Samuel Y, Harmouche Rola, Putman Rachel K, Ross James C, Martinez Fernando J, Choi Augustine M, Bowler Russell P, Regan Elizabeth A, Curtis Jeffrey L, Han MeiLan K, Boucher Richard C, O'Neal Wanda K, Hatabu Hiroto, Lynch David A, Rosas Ivan O, Hunninghake Gary M, San Jose Estepar Raul, Washko George R
Abstract excerpt
A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event...
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