Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features.

doi:10.1016/j.chest.2020.08.2115

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Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features.

Chest - 1 Feb 2021

Billatos Ehab, Ash Samuel Y, Duan Fenghai, Xu Ke, Romanoff Justin, Marques Helga, Moses Elizabeth, Han MeiLan K, Regan Elizabeth A, Bowler Russell P, Mason Stefanie E, Doyle Tracy J, San José Estépar Rubén, Rosas Ivan O, Ross James C, Xiao Xiaohui, Liu Hanqiao, Liu Gang, Sukumar Gauthaman, Wilkerson Matthew, Dalgard Clifton, Stevenson Christopher, Whitney Duncan, Aberle Denise, Spira Avrum, San José Estépar Raúl, Lenburg Marc E, Washko George R

Abstract excerpt

BACKGROUND: Chronic tobacco smoke exposure results in a broad range of lung pathologies including emphysema, airway disease and parenchymal fibrosis as well as a multitude of extra-pulmonary comorbidities. Prior work using CT imaging has identified several clinically relevant subgroups of smoking related lung disease, but these investigations have generally lacked organ specific molecular correlates. RESEARCH...

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PMID: 32946850
DOI: 10.1016/j.chest.2020.08.2115
PMCID: PMC8039011

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